Formulation and in vitro Evaluations of Paracetamol Orally Disintegrating Tablets

Orally disintegrating tablets are a solid dosage form compromising medicinal substances which disintegrate rapidly, generally within matter of seconds, when placed on the tongue. In this study, paracetamol orally was formulated and evaluated. Direct compression used to prepare 350 mg five formulations (F1- F5) by using single punch manual tableting machine. Pre-formulation studies were performed powder mixture each formulation obtain information regarding their flow properties. The from also evaluated for weight uniformity, drug content thickness, hardness, friability, disintegration dissolution. tests carried out revealed that F2 showed shortest time 32.67 ± 3.14 seconds followed F5, F3, F4 F1. However, dissolution results illustrated F5 have best profile, releasing 84.70 5.31% drugs 4 minutes. Hence most optimized tablet in study.